PERIPHERAL ADMINISTRATION OF LACTATE PROCUDES ANTIDEPRESSANT-LIKE EFFECT

Carrard A, Elsayed M, Margineanu M, Boury-Jamot B, Fragniere L, Meylan EM, Petit JM, Fiumelli H, Magistretti PJ, Martin JL.

Mol Psychiatry. 2016 Dec 6. doi: 10.1038/mp.2016.237.PMID: 27922608

In Vivo Evidence for a Lactate Gradient from Astrocytes to Neurons.

Mächler P, Wyss MT, Elsayed M, Stobart J, Gutierrez R, von Faber-Castell A, Kaelin V, Zuend M, San Martín A, Romero-Gómez I, Baeza-Lehnert F, Lengacher S, Schneider BL, Aebischer P, Magistretti PJ, Barros LF, Weber B.

Cell Metab. 2016 Jan 12;23(1):94-102. doi: 10.1016/j.cmet.2015.10.010. Epub 2015 Nov 19.PMID: 26698914

Improvement of Neuroenergetics by Hypertonic Lactate Therapy in Patients with Traumatic Brain Injury Is Dependent on Baseline Cerebral Lactate/Pyruvate Ratio.

Quintard H, Patet C, Zerlauth JB, Suys T, Bouzat P, Pellerin L, Meuli R, Magistretti PJ, Oddo M.

J Neurotrauma. 2016 Apr 1;33(7):681-7. doi: 10.1089/neu.2015.4057. Epub 2015 Dec 15.PMID: 26421521

Disrupting astrocyte-neuron lactate transfer persistently reduces conditioned responses to cocaine.

Boury-Jamot B, Carrard A, Martin JL, Halfon O, Magistretti PJ, Boutrel B.

Mol Psychiatry. 2016 Aug;21(8):1070-6. doi: 10.1038/mp.2015.157. Epub 2015 Oct 27.PMID: 26503760

Regulation of neuron-astrocyte metabolic coupling across the sleep-wake cycle.

Petit JM, Magistretti PJ.

Neuroscience. 2016 May 26;323:135-56. doi: 10.1016/j.neuroscience.2015.12.007. Epub 2015 Dec 17.PMID: 26704637

L-Lactate protects neurons against excitotoxicity: implication of an ATP-mediated signaling cascade.

Jourdain P, Allaman I, Rothenfusser K, Fiumelli H, Marquet P, Magistretti PJ.

Sci Rep. 2016 Feb 19;6:21250. doi: 10.1038/srep21250.PMID: 26893204

Sodium signaling and astrocyte energy metabolism.

Chatton JY, Magistretti PJ, Barros LF.

Glia. 2016 Mar 29. doi: 10.1002/glia.22971.Epub 2016 Mar 29.PMID: 27027636

A Role for Lactate in the Consolidation of Drug-Related Associative Memories.

Boutrel B, Magistretti PJ.

Biol Psychiatry. 2016 Jun 1;79(11):875-7. doi: 10.1016/j.biopsych.2016.04.010.PMID: 27198521

Imaging brain aerobic glycolysis as a marker of synaptic plasticity.

Magistretti PJ

Proc Natl Acad Sci U S A. 2016 Jun 28;113(26):7015-6. doi: 10.1073/pnas.1607423113. Epub 2016 Jun 17.PMID: 27317739

Astrocytic BETA 2-adrenergic receptors mediate hippocampal long-term memory consolidation.

Gao V, Suzuki A, Magistretti PJ, Lengacher S, Pollonini G, Steinman MQ, Alberini CM.

Proc Natl Acad Sci U S A. 2016 Jul 26;113(30):8526-31. doi: 10.1073/pnas.1605063113. Epub 2016 Jul 8.PMID: 27402767

Lactate release from astrocytes to neurons contributes to cocaine memory formation.

Boury-Jamot B, Halfon O, Magistretti PJ, Boutrel B.

Bioessays. 2016 Oct 4. doi: 10.1002/bies.201600118.PMID: 27699812

Deficiency in monocarboxylate transporter 1 (MCT1) in mice delays regeneration of peripheral nerves following sciatic nerve crush.

Morrison BM, Tsingalia A, Vidensky S, Lee Y, Jin L, Farah MH, Lengacher S, Magistretti PJ, Pellerin L, Rothstein JD.

Exp Neurol. 2015 Jan;263:325-38. doi: 10.1016/j.expneurol.2014.10.018. Epub 2014 Oct 29.PMID: 25447940

Neuroenergetic Response to Prolonged Cerebral Glucose Depletion after Severe Brain Injury and the Role of Lactate.

Patet C, Quintard H, Suys T, Bloch J, Daniel RT, Pellerin L, Magistretti PJ, Oddo M.

J Neurotrauma. 2015 Oct 15;32(20):1560-6. doi: 10.1089/neu.2014.3781. Epub 2015 May 26.PMID: 25790152

A cellular perspective on brain energy metabolism and functional imaging.

Magistretti PJ, Allaman I.

Neuron. 2015 May 20;86(4):883-901. doi: 10.1016/j.neuron.2015.03.035. PMID: 25996133

Astrocytes: New Targets for the Treatment of Neurodegenerative Diseases.

Finsterwald C, Magistretti PJ, Lengacher S.

Curr Pharm Des. 2015;21(25):3570-81. PMID: 26166612

Learning-Induced Gene Expression in the Hippocampus Reveals a Role of Neuron -Astrocyte Metabolic Coupling in Long Term Memory.

Tadi M, Allaman I, Lengacher S, Grenningloh G, Magistretti PJ.

PLoS One. 2015 Oct 29;10(10):e0141568. doi: 10.1371/journal.pone.0141568. eCollection 2015.PMID: 26513352

A New Outlook on Mental Illnesses: Glial Involvement Beyond the Glue.

Elsayed M, Magistretti PJ.

Front Cell Neurosci. 2015 Dec 16;9:468. doi: 10.3389/fncel.2015.00468. eCollection 2015. PMID: 26733803

Hypertonic lactate and the injured brain: facts and the potential for positive clinical implications.

Bouzat P, Magistretti PJ, Oddo M.

Intensive Care Med. 2014 Jun;40(6):920-1. doi: 10.1007/s00134-014-3312-x. Epub 2014 May 1. PMID: 24789621

Lactate promotes plasticity gene expression by potentiating NMDA signaling in neurons.

Yang J, Ruchti E, Petit JM, Jourdain P, Grenningloh G, Allaman I, Magistretti PJ.

Proc Natl Acad Sci U S A. 2014 Aug 19;111(33):12228-33. doi: 10.1073/pnas.1322912111. Epub 2014 Jul 28.PMID: 25071212

Alzheimer's disease: the amyloid hypothesis and the Inverse Warburg effect.

Demetrius LA, Magistretti PJ, Pellerin L.

Front Physiol. 2015 Jan 14;5:522. doi: 10.3389/fphys.2014.00522. eCollection 2014.PMID: 25642192

Synaptic plasticity and the Warburg effect.

Magistretti PJ.

Cell Metab. 2014 Jan 7;19(1):4-5. doi: 10.1016/j.cmet.2013.12.012.PMID: 24411936

Regulation of neurotrophic factors and energy metabolism by antidepressants in astrocytes.

Martin JL, Magistretti PJ, Allaman I.

Curr Drug Targets. 2013 Oct;14(11):1308-21. PMID: 23469874

Cerebral extracellular lactate increase is predominantly nonischemic in patients with severe traumatic brain injury.

Sala N, Suys T, Zerlauth JB, Bouzat P, Messerer M, Bloch J, Levivier M, Magistretti PJ, Meuli R, Oddo M.

J Cereb Blood Flow Metab. 2013 Nov;33(11):1815-22. doi: 10.1038/jcbfm.2013.142. Epub 2013 Aug 21.PMID: 23963367

Resistance to diet-induced obesity and associated metabolic perturbations in haploinsufficient monocarboxylate transporter 1 mice.

Lengacher S, Nehiri-Sitayeb T, Steiner N, Carneiro L, Favrod C, Preitner F, Thorens B, Stehle JC, Dix L, Pralong F, Magistretti PJ, Pellerin L.

PLoS One. 2013 Dec 18;8(12):e82505. doi: 10.1371/journal.pone.0082505. eCollection 2013.PMID: 24367518

Oligodendroglia metabolically support axons and contribute to neurodegeneration.

Lee Y, Morrison BM, Li Y, Lengacher S, Farah MH, Hoffman PN, Liu Y, Tsingalia A, Jin L, Zhang PW, Pellerin L, Magistretti PJ, Rothstein JD.

Nature. 2012 Jul 26;487(7408):443-8. doi: 10.1038/nature11314.PMID: 22801498

New evidence of neuroprotection by lactate after transient focal cerebral ischaemia: extended benefit after intracerebroventricular injection and efficacy of intravenous administration.

Berthet C, Castillo X, Magistretti PJ, Hirt L.

Cerebrovasc Dis. 2012;34(5-6):329-35. doi: 10.1159/000343657. Epub 2012 Nov 14.PMID: 23154656

Neuron-glia metabolic coupling and plasticity.

Magistretti PJ.

Exp Physiol. 2011 Apr;96(4):407-10. doi: 10.1113/expphysiol.2010.053157. Epub 2010 Dec 1.PMID: 21123364

Astrocyte-neuron metabolic relationships: for better and for worse.

Belanger M, Allaman I, Magistretti PJ.

Trends Neurosci. 2011 Feb;34(2):76-87. doi: 10.1016/j.tins.2010.12.001. Epub 2011 Jan 13. PMID: 21236501

Astrocyte-neuron lactate transport is required for long-term memory formation.

Suzuki A, Stern SA, Bozdagi O, Huntley GW, Walker RH, Magistretti PJ, Alberini CM.

Cell. 2011 Mar 4;144(5):810-23. doi: 10.1016/j.cell.2011.02.018.PMID: 21376239

Glutamate transport decreases mitochondrial pH and modulates oxidative metabolism in astrocytes.

Azarias G, Perreten H, Lengacher S, Poburko D, Demaurex N, Magistretti PJ, Chatton JY.

J Neurosci. 2011 Mar 9;31(10):3550-9. doi: 10.1523/JNEUROSCI.4378-10.2011.PMID: 21389211

In vivo evidence for lactate as a neuronal energy source.

Wyss MT, Jolivet R, Buck A, Magistretti PJ, Weber B.

J Neurosci. 2011 May 18;31(20):7477-85. doi: 10.1523/JNEUROSCI.0415-11.2011.PMID: 21593331

Altered glycogen metabolism in cultured astrocytes from mice with chronic glutathione deficit; relevance for neuroenergetics in schizophrenia.

Lavoie S, Allaman I, Petit JM, Do KQ, Magistretti PJ.

PLoS One. 2011;6(7):e22875. doi: 10.1371/journal.pone.0022875. Epub 2011 Jul 28.PMID: 21829542

Sweet sixteen for ANLS.

Pellerin L, Magistretti PJ.

J Cereb Blood Flow Metab. 2012 Jul;32(7):1152-66. doi: 10.1038/jcbfm.2011.149. Epub 2011 Oct 26.PMID: 22027938

Brain energy metabolism: focus on astrocyte-neuron metabolic cooperation.

Bélanger M, Allaman I, Magistretti PJ.

Cell Metab. 2011 Dec 7;14(6):724-38. doi: 10.1016/j.cmet.2011.08.016. Review.PMID: 22152301

Amyloid-beta aggregates cause alterations of astrocytic metabolic phenotype: impact on neuronal viability.

Allaman I, Gavillet M, Belanger M, Laroche T, Viertl D, Lashuel HA, Magistretti PJ.

J Neurosci. 2010 Mar 3;30(9):3326-38. doi: 10.1523/JNEUROSCI.5098-09.2010.PMID: 20203192

The role of astroglia in neuroprotection.

Bélanger M, Magistretti PJ.

Dialogues Clin Neurosci. 2009;11(3):281-95.PMID: 19877496